ParkinsonCanadaV1, Main, Exploration, bibRecord, 004D01

The effect of chlorpromazine on monoamine levels in the rat cerebellum and hippocampus: a developmental study

Identifieur interne : 004D01 ( Main/Exploration ); précédent : 004D00; suivant : 004D02

The effect of chlorpromazine on monoamine levels in the rat cerebellum and hippocampus: a developmental study

Auteurs : R. S. Hannah [Canada] ; D. Parkinson [Canada] ; A. W. Spira [Canada] ; S. H. Roth [Canada]

Source :

Neuroscience Letters [ 0304-3940 ] ; 1987.

RBID : ISTEX:EE404A511F717061C879AACC986B50BD21A55D9E

English descriptors

KwdEn :
- Animals, Cerebellum (analysis), Cerebellum (drug effects), Cerebellum (growth & development), Chlorpromazine (pharmacology), Dopamine (analysis), Female, Fetus (drug effects), Hippocampus (analysis), Hippocampus (drug effects), Hippocampus (growth & development), Norepinephrine (analysis), Pregnancy, Rats, Serotonin (analysis).
MESH :
- chemical , analysis : Dopamine, Norepinephrine, Serotonin.
- chemical , pharmacology : Chlorpromazine.
- analysis : Cerebellum, Hippocampus.
- drug effects : Cerebellum, Fetus, Hippocampus.
- growth & development : Cerebellum, Hippocampus.
- Animals, Female, Pregnancy, Rats.

Abstract

Acute and chronic alterations of the monoamine levels in the rat cerebellum and hippocampus after late prenatal and early postnatal administration of chlorpromazine, were examined using high performance liquid chromatography with electrochemical detection. During a critical phase of development (one week postnatal), chlorpromazine produced increased levels of both serotonin and dopamine in both brain regions. At 24 weeks postnatal, or 21 weeks after cessation of drug administration, the levels of all 3 monoamines were decreased in the cerebellum and increased in the hippocampus. The early disruption in the normal monoamine levels may be related to abnormal growth patterns observed in previous studies.

Url:

https://api-v5.istex.fr/document/EE404A511F717061C879AACC986B50BD21A55D9E/fulltext/pdf

DOI: 10.1016/0304-3940(87)90685-9

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">Acute and chronic alterations of the monoamine levels in the rat cerebellum and hippocampus after late prenatal and early postnatal administration of chlorpromazine, were examined using high performance liquid chromatography with electrochemical detection. During a critical phase of development (one week postnatal), chlorpromazine produced increased levels of both serotonin and dopamine in both brain regions. At 24 weeks postnatal, or 21 weeks after cessation of drug administration, the levels of all 3 monoamines were decreased in the cerebellum and increased in the hippocampus. The early disruption in the normal monoamine levels may be related to abnormal growth patterns observed in previous studies.</div>
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La maladie de Parkinson au Canada (serveur d'exploration)

The effect of chlorpromazine on monoamine levels in the rat cerebellum and hippocampus: a developmental study

The effect of chlorpromazine on monoamine levels in the rat cerebellum and hippocampus: a developmental study

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

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Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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